Ma, Y, Kochunov, P., Kvarta, M.K., LeGates, T.A., Adhikari B.M., Chiappelli, J, van der Vaart, A., Goldwaser, E.L., Bruce, H., Hatch, K.S., Gao, G., Chen, S., Summerfelt, A., Nichols, T.E., Hong, L.E. Reciprocal Relationships between Stress and Depression: the Essential Role of the Nucleus Accumbens. Psychological Medicine. Sep 26:1-12, 2023. PMID: 37750294.
Copenhaver, A.E., Roberts, R.C., LeGates, T.A. Light-dependent effects on mood: mechanistic insights from animal models. Prog Brain Res. 273(1): 71-95. 2022. PMID: 35940725
Ramsey A.M*., Tang, A.H*, LeGates, T.A., Gou, X.Z., Carbone, B.E., Thompson, S.M., Biederer, T, and Blanpied, T.A. Subsynaptic positioning of AMPARs by LRRTM2 controls synaptic strength. Science Advances. 7(34), 2021. PMID: 34417170
LeGates, T.A. The reward integrator. Science. 370(6512):46, 2020. PMID: 33004507
LeGates, T.A., Kvarta, M.D. News and Views: Illuminating a path from light to depression. Nature Neuroscience. 23(7):785-787, 2020. PMID: 32555525
LeGates, T.A., Kvarta, M.D., Thompson, S.M. Sex differences in antidepressant efficacy. Neuropsychopharmacology Reviews. 44: 140-154, 2019. PMID: 30082889
LeGates, T.A., Kvarta, M.D., Tooley, J.R., Francis, T.C., Lobo, M.K., Creed, M.C., and Thompson, S.M., Reward behavior is regulated by the strength of hippocampus-nucleus accumbens synapses. Nature. 564: 258-262, 2018. PMID:30478293
Divakaruni, S, Van Dyke, A.M, Chandra, R, LeGates, T.A., Contreras, M, Dharmasri, P.A., Higgs, H.N., Lobo, M.K., Thompson, S.M., and Blanpied, T.A. Long-term potentiation requires a rapid burst of dendritic mitochondrial fission during induction. Neuron. 100: 860-875, 2018. PMID:30318410
Chen, C.M, Orefice, L, Chiu, S.L, LeGates, T.A., Hattar, S, Huganir, R, Zhao,H, Xu, B and Kuruvilla, R. Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice. Natl. Acad. Sci. USA. 114: E619-E628, 2017. PMID:28069946
Bedont, J.L, LeGates, T.A., Buhr, E, Bathini, A, Ling, J, Wong, P, van Gelder, R, Hattar, S*, Mongrain, V, Blackshaw, S*, An Lhx1-Regulated Transcriptional Network Controls Sleep/Wake Coupling and Thermal Resistance of the Central Circadian Clockworks. Curr. Biol. 27: 128-136, 2017. PMID:28017605
Le, N.T., Chang, L, Kovlyagina, I, Georgiou, P, Safren, N, Braunstein, K.E., Kvarta, M.D., Van Dyke, A.M., LeGates, T.A., Philips, T, Morrison, B.M., Thompson, S.M., Puche, A.C., Gould, T.D., Rothstein, J.D., Wong, P.C., Monteiro, M.J. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS–FTD-linked UBQLN2 Proc. Natl. Acad. Sci. USA. 113: E7580-E7589, 2016. PMID:27834214.
Jaaro-Peled, H, Altimus, C, LeGates, T.A., Cash-Padgett, T, Zoubovsky, S, Hikida, T, Ishizuka, K, Hattar, S, Mongrain, V, Sawa, A. Abnormal wake/sleep pattern in a novel gain-of-function model of DISC1. Neuroscience Research. Neurosci. Res. 112: 63-69, 2016. PMID:27354230
Fischell, J, Van Dyke, A.M., Kvarta M.D., LeGates, T.A., and Thompson, S.M. A benzodiazepine receptor inverse agonist exerts a rapid antidepressant action and restores stress-induced impairment of excitatory synaptic strength. 40: 2499-2509, 2015. PMID:25900119
Thompson, S.M., Kallarackal, A.J., Kvarta, M.D., Van Dyke, A.M., LeGates, T.A., Cai, X. An excitatory synapse hypothesis of depression. Trends Neurosci. 38: 279-294, 2015. PMID:25887240
LeGates, T.A., Fernandez, D.C., Hattar, S. Light as a central modulator of circadian rhythms, sleep and affect. Nat Rev Neurosci. 15: 443-454, 2014. PMID: 24917305
Bedont, J.L.*, LeGates, T.A.*, Slat, E.A., Wang, H, Hu, J, Byerly, M.S., Wong, G.W., Qian, J, Herzog, E.D., Hattar,S , and Blackshaw, S. Lhx1 controls both terminal differentiation and circadian function of the suprachiasmatic nucleus. Cell Reports. pii: S2211-1247(14)00257-5, 2014. PMID: 24767996
LeGates, T.A.*, Altimus, C.A.*, Wang, H, Lee, H-K, Yang, S, Kirkwood, A, Zhao, H, Weber, E.T., Hattar, S. Aberrant light exposure impairs learning and mood predominantly through melanopsin cells. Nature 491: 594-598, 2012. PMID: 23151476
Ecker, J.L., Dumitrescu, O.N., Wong, K.Y., Alam, N., Chen, S.-K., LeGates, T.A., Prusky, G., Berson, D.M., and Hattar, S. Melanopsin-expressing retinal ganglion photoreceptors encompass diverse cell types and process spatial visual signals. Neuron 67: 49-60, 2010. PMID:20624591
Altimus, C.M., LeGates, T.A., Hattar, S. Circadian and Light effects on Mood Regulation. Chapter in Mouse Models of Mood and Anxiety disorders, NeuroMethods, 42, 47-65, 2009. Humana Press, New York, NY.
LeGates T.A., Dunn D, Weber E.T. Accelerated re-entrainment to advanced light cycles in BALB/cJ mice. Physiol Behav. 98:427-432, 2009. PMID 19619568
Altimus, C.M., Guler A.D., Villa K.L., McNeill D.M., LeGates T.A., Hattar S. Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation. Proc. Natl. Acad. Sci. USA. 105: 19998-20003, 2008. PMID 19060203